E-ISSN 1305-3612
Abdominal Imaging - Original Article
Focal nodular hyperplasia: a weight-based, intraindividual comparison of gadobenate dimeglumine and gadoxetate disodium-enhanced Magnetic Resonance Imaging
1 Department of Radiology, Palermo University Hospital, Palermo, Italy  
Diagn Interv Radiol ; : -

Abstract

Purpose: To qualitatively and quantitatively compare the enhancement pattern of focal nodular hyperplasia after gadobenate dimeglumine and gadoxetate disodium injection in the same patient.


Methods
: 1.5-T MR examinations of 16 patients with 21 focal nodular hyperplasias, studied after the injection of both contrast-media, were evaluated. Both MR imaging studies were performed in all patients. A qualitative analysis was performed evaluating each lesion in all phases. For quantitative analysis we calculated signal intensity ratio, lesion-to-liver contrast ratio and liver parenchyma signal intensity gain on hepatobiliary phase. Statistical analysis was performed with the Wilcoxon sign-rank test for clustered paired data and the McNemar test for paired frequencies. A p value < 0.05 was considered statistically significant.


Results
: At qualitative analysis no statistical significant differences were evident during all contrast-enhanced phases. Signal intensity ratio (p=0.048), lesion-to-liver contrast ratio (p=0.032) and liver parenchyma signal intensity gain (p=0.012) were significantly higher on hepatobiliary phase after gadoxetate disodium injection.


Conclusion
: There were no significant differences in the MR imaging findings of focal nodular hyperplasia after the injection of a weight-based dose of either gadobenate dimeglumine or gadoxetate disodium.

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