Purpose: To explore whether intravoxel incoherent motion (IVIM)-related parameters of hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH) demonstrate differences that could be used to differentiate and improve diagnostic efficiency.
Methods: Twenty-seven patients, including twenty-two with HCC and five with FNH, underwent liver 3.0T magnetic resonance imaging for routine sequences. They were also examined by IVIM-diffusion-weighted imaging (DWI) scanning with 11 b values (0–800 s/mm2) concurrently. IVIM-derived parameters, such as the pure diffusion coefficient (D), the pseudo-diffusion coefficient (D*), the perfusion fraction (F), and the apparent diffusion coefficient (ADCtotal), were quantified automatically by post-processing software and compared between the two groups. A receiver operating characteristic (ROC) curve was then created to predict their diagnostic value.
Results: D* was weak for reproducibility among all parameters. ADCtotal, D, and D* were significantly lower in the HCC group than in the FNH group, whereas F did not show a significant difference. ADCtotal and D had the largest area under the curve values (AUC; 0.915 and 0.897, respectively) and similarly high efficacy to differentiate the two conditions.
Conclusion: IVIM provides a new modality to differentiate the HCC and FNH. ADCtotal and D demonstrated outstanding and comparable diagnosing utility.