E-ISSN 1305-3612
1 Division of Pediatric Radiology, Clinic of Diagnostic and Interventional Radiology, University of Heidelberg, Germany  
2 Department of Visceral- and Transplantation Surgery, University of Heidelberg, Germany  
3 Clinic I, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Germany  
4 Division of Pediatric Nephrology, Clinic I, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Germany  
Diagn Interv Radiol ; : -


Purpose: To evaluate if ARFI-Shear Wave Elastography (SWE) can detect change of parenchymal stiffness in an ex vivo pig kidney model of acute urinary tract obstruction.


Methods: 20 heparinized pig kidneys were investigated at 10 intrapelvic hydrostatic pressure steps (0 to 90 mmHg). SWE (ARFI; Virtual TouchTM IQ, Siemens/Germany) measurements were taken at three different measuring regions and in two measuring sequences using a linear ultrasound probe (9L4, Siemens, Erlangen, Germany). Median values of 10 shear wave speed (SWS) measurements were calculated for each pressure step. Logarithmic transformed median SWS values were analyzed in a linear mixed model.


Results: SWS increased significantly with increasing intrapelvic pressure. Median SWS for all kidneys in both measuring sequences and all measuring regions was 1.47 m/s (interquartile range (IQR) 0.38 m/s) at a pressure level of 0 mmHg, 1.94 m/s (IQR 0.42 m/s) at 30 mmHg, 2.07 m/s (IQR 0.43 m/s) at 60 mmHg, 2.24 m/s (IQR 0.49 m/s) at 90 mmHg. The correlation between pelvic pressure increase and median SWS values for the central parenchyma region was significantly higher compared to the peripheral parenchyma.


Conclusion: Acutely increased renal pelvic pressure correlates with increasing SWS values in ARFI elastography in an ex vivo porcine kidney model.

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