E-ISSN 1305-3612
Interventional Radiology - Original Article
Trans-arterial embolization of renal cell carcinoma as an adjunctive therapy prior to cryoablation: a propensity score matching analysis
1 Division of Interventional Radiology, Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA  
2 Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA  
3 Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA  
Diagn Interv Radiol ; : -

Abstract

 

Purpose: To assess the safety and efficacy of trans-arterial embolization (TAE) prior to percutaneous cryoablation (PCA) in the management of RCC compared to PCA alone using a propensity score matching analysis to minimize confounding factors.

 

Methods: A retrospective review of all PCAs performed for renal masses identified nine patients who underwent TAE prior to PCA. These patients were matched in a 2:1 ratio with patients who underwent PCA only using age, gender, and tumor size to create the propensity score model for matching. Other demographic, clinical, and outcomes data were collected.

 

Results: The TAE+PCA group included 5 males and 4 females with a mean age of 67.9 years and mean tumor diameter of 51.7mm. The PCA only group included 11 males and 7 females with a mean age of 66.8 years and mean tumor diameter of 46.2mm. No significant differences in these propensity score matched characteristics were identified. Further, the groups had no significant differences in tumor geometry (p=0.831), R.E.N.A.L. nephrometry scores (p=0.144), or co-morbidity indices (p=0.392). TAE was technically successful and without complication in all cases. PCA was technically successful in 8/9 patients in the TAE+PCA group and in 14/18 patients in the PCA only group (p=0.483). No significant differences in the rate of complications (p=0.483), change in eGFR (p=0.691), or change in hematocrit (p=0.152) were identified between the two groups.

 

Conclusion: TAE of RCC prior to PCA is safe and technically feasible; although, no objective benefits over PCA alone were identified by propensity score matching analysis.

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