E-ISSN 1305-3612
1 Department of Medical Imaging and Interventional Radiology; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China  
2 Department of Medical Imaging and Interventional Radiology; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China  
3 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China;  
Diagn Interv Radiol ; : -

Abstract

 

Purpose: To compare the clinical efficacy of combination therapy of transarterial chemoembolization (TACE) and microwave ablation (MWA) with TACE monotherapy in BCLC stage B HCC patients with tumor size ≤ 7cm and tumor number ≤ 5.

 

Methods: We retrospectively reviewed 150 BCLC stage B HCC patients who had received TACE monotherapy or TACE-MWA combination therapy in our hospital from March 2007 to April 2016. The patients were matched by propensity score at the ratio of 1:2 by optimal method. The median follow-up period was 16.23 months. The overall survival (OS), tumor response and progression-free survival (PFS) were compared between the two groups by Kaplan–Meier method and Log rank test.

 

Results: The tumor control rates (CR+PR+SD) of 6, 12, 18, 24 months for TACE group were 55.5%, 37.3%, 21.3%, 15.8%, and for TACE-MWA group were 74.0%, 47.8%, 35.0%, 31.8%, respectively. The survival rate of 1, 3, 5 years for TACE group were 77.5%, 42.1%, 21.0% and for TACE-MWA group were 93.1%, 79.0%, 67.7%, respectively. Compared to TACE group, the TACE-MWA group had significant improved PFS rates (P=0.044) and OS rates (P=0.002).

 

Conclusion: TACE-MWA combination therapy has better clinical efficacy than TACE monotherapy in BCLC stage B patients with tumor size ≤7cm and tumor number ≤5.

Key Words
Authors
All
Author's Corner
Reviewer's Corner
Survey
Copyright © Turkish Society of Radiology | Latest Update: 04.05.2018