E-ISSN 1305-3612
Cardiovascular Imaging - Original Article
Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry
1 Division of Radiology, Department of Medicine and Surgery, University of Parma, Parma, Italy  
2 Department of Radiology, University of Palermo, Palermo, Italy  
3 Department of Medicine and Surgery, University of Parma, Parma, Italy,.  
4 Division of Radiology, Department of Medicine and Surgery, University of Parma, Parma; Department of Radiology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy  
5 Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy  
6 Cardiovascular Imaging Center, SDN Foundation IRCCS, Naples, Italy  
7 Division of Endocrinology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy  
Diagn Interv Radiol ; : -

Abstract

Purpose: To assess the association between features of epicardial adipose tissue (EAT) and demographic, morphometric and clinical data, in a large population of symptomatic patients with clinical indication to cardiac CT angiography (CCTA).

 

Methods: Epicardial fat volume (EFV) and adipose CT density of 1,379 patients undergoing CCTA (918 men, 66.6%; age range was 18 - 93 years, median 64 years) were semi-automatically quantified. Clinical variables were compared between diabetic and non-diabetic patients to assess potential differences in EFV and adipose CT density. Multiple regression models were calculated to find the clinical variables with a significant association with EFV and adipose CT density.

 

Results: The median EFV in diabetic patients (112.87 mL) was higher compared with non-diabetic patients (82.62 mL; P < 0.0001). The explanatory model of the multivariable analysis showed the strongest associations between EFV and BMI (Beta=0.442) and age (Beta=0.365). Significant yet minor association was found with sex (Beta=0.203), arterial hypertension (Beta=0.072), active smoking (Beta=0.068), diabetes (Beta=0.068), hypercholesterolemia (Beta=0.046) and cardiac height (Beta=0.118). The mean density of EAT was associated with BMI (Beta=0.384), age (Beta=0.105), smoking (Beta=0.088), and diabetes (Beta=0.085).

 

Conclusion: In a large population of symptomatic patients, EFV is higher in diabetic patients compared with non-diabetic patients. Clinical variables are associated with quantitative features of epicardial fat.

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