E-ISSN 1305-3612
Abdominal Imaging - Original Article
Multimodality imaging studies of intraductal tubulopapillary neoplasms of the pancreas
1 Department of Radiology, Ajou University School of Medicine, Suwon, Korea;Department of Radiology and Research Institute of Radiological Science, Severance Hospital Yonsei University School of Medicine, Seoul, Korea  
2 -Department of Radiology and Research Institute of Radiological Science, Severance Hospital Yonsei University School of Medicine, Seoul, Korea  
3 Department of Pathology, Severance Hospital Yonsei University School of Medicine, Seoul, Korea  
4 -Department of Radiology, Ajou University School of Medicine, Suwon, Korea  
Diagn Interv Radiol ; : -

Abstract

PURPOSE: We investigated multimodality imaging findings of intraductal tubulopapillary neoplasms (ITPN) of the pancreas.

 

METHODS: This study was approved by the institutional review board with waived informed consent. A total of eight patients were histopathologically diagnosed with pancreatic ITPN in a single institution over a 6-year period. The imaging findings of dynamic contrast-enhanced computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasound (EUS), and positron emission tomography-CT (PET-CT) were reviewed and correlated with clinicopathological findings.

 

RESULTS: Histopathologically, an invasive carcinoma component was found in 5 of 8 (62.5%) patients. The median diameter of the lesions and the main pancreatic ducts was larger in ITPN with invasive carcinoma (19 mm, 13.3-98.0 mm; and 13 mm, 5.9-16.3 mm, respectively) than in ITPN without invasive carcinoma (13 mm, 12.7-18.5 mm; and 6 mm, 5.6-6.1 mm, respectively), but not significantly (lesions, P = 0.229 and main pancreatic ducts, P = 0.143). Pancreatolithiasis was accompanied by 3 of 5 (60%) patients with invasive carcinoma. Intraductal solid tumors were demonstrated on CT (5/8, 62.5%), MRCP (5/7, 71.4%), and EUS (7/7, 100%). In addition, various imaging findings mimicking chronic autoimmune pancreatitis or pancreatic ductal adenocarcinoma were found in 3 (37.5%) patients on multimodality imaging. The lesion multiplicity and synchronous or metachronous biliary cancer occurred in 3 (37.5%) patients, respectively.

 

CONCLUSION: Patients with associated invasive carcinoma from pancreatic ITPN may have presented a trend toward larger tumor size and dilated pancreatic duct with pancreaticoliths, but not statistically significant. Further studies with a larger number of patients are needed to provide better insight into these findings. Pancreatic ITPN can show various atypical imaging findings as well as typical intraductal solid tumor on multimodality imaging. The presence of lesion multiplicity and synchronous or metachronous biliary cancer can be helpful for assisting with the diagnosis of pancreatic ITPN.

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