A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization
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Interventional Radiology - Case Report 2016
P: 76-80
January 2013

A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization

Diagn Interv Radiol 2013;19(1):76-80
1. School of Life and Health Sciences, Adikavi Nannaya University, Rajahmundry/AP, India
2. Department of Radiology, Chung-Ang University College of Medicine, Seoul, Republic of Korea
3. Department of Orthopedic Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea
4. Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea
5. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea
6. Biologics Research Division, Korea Food and Drug Administration, Chungbuk, Republic of Korea
No information available.
No information available
Received Date: 28.03.2012
Accepted Date: 24.05.2012
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ABSTRACT

A 61-year-old male patient with atherosclerotic critical limb ischemia in the left leg underwent stent insertion into the left superficial femoral artery. Stenting procedures improved Rutherford grade from III-5 to II-4. Granulocyte colony-stimulating factor stimulated the production of white blood cells over four-fold and mononuclear cells (MNCs) 1.5-fold in the whole blood. Transplantation of 7.9×10 9 autologous MNCs into the left femoral artery rapidly decreased the leg pain intensity, with further improvement of Rutherford grades from II-4 to 0-0 without any side effects. In the four-year follow-up, significant improvement was found in terms of ankle brachial index, from nondetectable to 0.67, and peak systolic velocity, from 14.8 to 36.1 cm/s. Limb salvage and decreased resting pain were the notable outcomes of the treatment.