E-ISSN: 1305-3612
Abnormal spontaneous brain activity in minimal hepatic encephalopathy: resting-state fMRI study
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Neuroradiology - Original Article
VOLUME: 22 ISSUE: 2
P: 196-200
March 2016

Abnormal spontaneous brain activity in minimal hepatic encephalopathy: resting-state fMRI study

Diagn Interv Radiol 2016;22(2):196-200
DOI: 10.5152/dir.2015.15208
Wei-Jia Zhong
Zhi-Ming Zhou
Jian-Nong Zhao
Wei Wu
Da-Jing Guo
1. Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
No information available.
No information available
Received Date: 31.05.2015
Accepted Date: 06.08.2015
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ABSTRACT

PURPOSE

We aimed to assess the abnormality of baseline spontaneous brain activity in minimal hepatic encephalopathy (MHE) by amplitude of low frequency fluctuation (ALFF) and fraction ALFF (fALFF).

METHODS

A total of 14 MHE patients and 14 healthy controls were included in our study. Both ALFF and fALFF of functional magnetic resonance imaging were calculated for statistical analysis.

RESULTS

Compared with healthy controls, patients with MHE had significantly decreased ALFF in the bilateral medial prefrontal cortex (MPFC), left superior frontal gyrus, right precentral gyrus, left opercular part of inferior frontal gyrus, left gyrus rectus, bilateral precuneus, and the posterior lobe of right cerebellum; and they had significantly decreased fALFF in the bilateral MPFC, right middle frontal gyrus, right superior temporal gyrus, and the posterior lobe of left cerebellum.

CONCLUSION

ALFF and fALFF changes in many brain regions demonstrate abnormality of the spontaneous neuronal activity in MHE. Especially the impairment of right precuneus and left MPFC may play a critical role in manifestation of MHE. Changes of ALFF and fALFF in the precuneus and the MPFC can be used as a potential marker for MHE.