E-ISSN: 1305-3612
    Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk
    PDF
    Cite
    Share
    Request
    Chest Imaging - Original Article
    VOLUME: 18 ISSUE: 6
    P: 531-536
    November 2012

    Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk

    Diagn Interv Radiol 2012;18(6):531-536
    DOI: 10.4261/1305-3825.DIR.5827-12.3
    Enes Elvin Gül 1
    İlknur Can 2
    İbrahim Güler 3
    Ahmet Yeşildağ 4
    Turyan Abdülhalikov 2
    Mehmet Kayrak 5
    Kurtuluş Özdemir 2
    Hasan Gök 2
    1. Departments of Hematology, Selçuk University Meram School of Medicine, Meram, Konya, Turkey
    2. Departments of Cardiology, Konya University Meram School of Medicine, Konya, Turkey
    3. Department of Radiology, Selcuk University Faculty of Medicine, Konya, Turkey
    4. Department of Radiology , Süleyman Demirel University Faculty of Medicine, İsparta, Turkey
    5. Departments of Radiology, Selçuk University Meram School of Medicine, Meram, Konya, Turkey
    No information available.
    No information available
    Received Date: 16.03.2012
    Accepted Date: 13.06.2012
    PDF
    Cite
    Share
    Request

    ABSTRACT

    PURPOSE

    Heart-type fatty acid binding protein (H-FABP) is a sensitive marker of myocardial injury and predictor of worse prognosis in patients with pulmonary embolism (PE). Assessment of right ventricular dysfunction and pulmonary artery obstruction index (PAOI) with computed tomography (CT) has been reported as a predictor of mortality in PE. Therefore, we aimed to assess the correlation between H-FABP and CT angiographic PAOI in PE patients at intermediate risk.

    MATERIALS AND METHODS

    Sixty-one patients (28 males; mean age, 62±17 years) with diagnosis of PE were included in this study. CT was performed in all patients, and the following parameters were evaluated: right ventricle/left ventricle ratio (RV/LV), pulmonary artery axial diameter, superior vena cava axial diameter, and PAOI determined with Qanadli score. Blood samples were assessed for H-FABP and troponin levels. Patients were followed for 30 days after discharge.

    RESULTS

    Mean PAOI was 57±18%. Eleven patients died during the follow-up period due to PE (18% mortality rate). H-FABP was positive in 21 patients (35%). There was no difference in CT parameters between patients with positive H-FABP and negative H-FABP. In addition, CT parameters were similar between patients who survived and those who did not. RV/LV ratio correlated with PAOI score. Among the biomarkers, troponin levels correlated with both RV/LV ratio and PAOI. H-FABP was an independent predictor of mortality. PAOI and RV/LV ratio did not predict 30-day mortality.

    CONCLUSION

    Although H-FABP positivity confers a bad prognosis on PE patients at intermediate risk, PAOI did not predict mortality in this group.

    Keywords: pulmonary embolism • heart-type fatty acid-binding protein • computed tomography • pulmonary artery obstructioninde

    References

    2024 ©️ Galenos Publishing House