E-ISSN: 1305-3612
    Flow characteristics of the proximal pulmonary arteries and vena cava in patients with chronic thromboembolic pulmonary hypertension: correlation between 3.0 T phase-contrast MRI and right heart catheterization
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    Chest Imaging - Original Article
    VOLUME: 20 ISSUE: 5
    P: 414-420
    September 2014

    Flow characteristics of the proximal pulmonary arteries and vena cava in patients with chronic thromboembolic pulmonary hypertension: correlation between 3.0 T phase-contrast MRI and right heart catheterization

    Diagn Interv Radiol 2014;20(5):414-420
    DOI: 10.5152/dir.2014.13501
    Xiaojuan Guo 1
    Min Liu 1
    Zhanhong Ma 1
    Shuangkun Wang 1
    Yuanhua Yang 2
    Zhenguo Zhai 2
    Chen Wang 2
    Renyou Zhai 1
    1. Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
    2. Respiratory Diseases Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
    No information available.
    No information available
    Received Date: 09.01.2014
    Accepted Date: 21.04.2014
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    ABSTRACT

    PURPOSE

    We aimed to determine the correlation between flow characteristics of the proximal pulmonary arteries and vena cava obtained by 3.0 T phase-contrast magnetic resonance imaging (MRI) and hemodynamic characteristics by right heart catheterization in patients with chronic thromboembolic pulmonary hypertension.

    MATERIALS AND METHODS

    Twenty consecutive patients with chronic thromboembolic pulmonary hypertension and 20 sex- and age-matched healthy volunteers were included prospectively. All patients and controls underwent phase-contrast MRI to determine the flow characteristics including peak velocity, mean velocity, and mean blood flow of the proximal pulmonary artery and vena cava. All patients underwent right heart catheterization to determine the hemodynamics.

    RESULTS

    Peak velocity and mean velocity of the proximal pulmonary artery were significantly lower in the patient group. In patients, both peak velocity and mean blood flow were sequentially decreased in the main pulmonary artery, left and right pulmonary arteries, and left and right interlobar pulmonary arteries. Inferior vena cava had higher peak velocity, mean velocity, and mean blood flow than superior vena cava. Peak velocity of the main pulmonary artery correlated with mean and diastolic pulmonary artery pressure. Peak velocity of both inferior and superior vena cava strongly correlated with the pulmonary vascular resistance index (PVRI) (r=-0.68, P < 0.001 and r=-0.74, P < 0.001, respectively). Mean velocity of the main pulmonary artery and right pulmonary artery strongly correlated with PVRI and mean pulmonary artery pressure. Mean velocity of the superior vena cava and mean blood flow of the main pulmonary artery strongly correlated with PVRI and right cardiac work index.

    CONCLUSION

    Blood flow in the proximal pulmonary artery and vena cava evaluated by phase-contrast MRI correlate with hemodynamic parameters of right heart catheterization and can be used to noninvasively evaluate the severity of chronic thromboembolic pulmonary hypertension and, potentially, to follow up the treatment response.

    References

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