Irreversible electroporation: evolution of a laboratory technique in interventional oncology

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Interventional Radiology - Original Article

VOLUME: 20 ISSUE: 2

P: 147-154

March 2014

Irreversible electroporation: evolution of a laboratory technique in interventional oncology

Diagn Interv Radiol 2014;20(2):147-154

DOI: 10.5152/dir.2013.13304

Amy R. Deipolyi, ¹

Alexander Golberg, ²

Martin L. Yarmush, ³

Ronald S. Arellano, ⁴

Rahmi Oklu ⁵

1. Division of Vascular Imaging and Interventions, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

2. From the Department of Imaging, Division of Interventional Radiology and the Center for Engineering in Medicine Massachusetts General Hospital, Harvard Medical School, Boston, USA.

3. From the Department of Imaging, Division of Interventional Radiology and the Center for Engineering in Medicine Massachusetts General Hospital, Harvard Medical School, Boston, USA

4. From the Department of Imaging, Division of Interventional Radiology Massachusetts General Hospital, Harvard Medical School, Boston, USA.

5. Department of Vascular Imaging and Interventions, Harvard University Medical School, Massachusetts General Hospital, Massachusetts, USA

No information available.

No information available

Received Date: 20.07.2013

Accepted Date: 26.12.2013

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ABSTRACT

Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.

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