E-ISSN: 1305-3612
Measurement of real-time tissue elastography in a phantom model and comparison with transient elastography in pediatric patients with liver diseases
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Pediatric Radiology - Original Article
VOLUME: 20 ISSUE: 1
P: 90-99
January 2014

Measurement of real-time tissue elastography in a phantom model and comparison with transient elastography in pediatric patients with liver diseases

Diagn Interv Radiol 2014;20(1):90-99
DOI: 10.5152/dir.2013.13116
Jens-Peter Schenk, 1
Gerhard Alzen, 2
Volker Klingmüller, 3
Ulrike Teufel, 4
Saroa El Sakka, 5
Guido Engelmann, 6
Buket Selmi 1
1. From the Division of Pediatric Radiology Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, German
2. From the Department of Pediatric Radiology University Clinic Giessen & Marburg, Giessen, Germany;
3. From the Department of Pediatric Radiology University Clinic Giessen & Marburg, Giessen, Germany
4. From the Department of General Pediatrics University Hospital of Heidelberg, Germany.
5. From the Division of Pediatric Radiology Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany
6. From the Department of General Pediatrics University Hospital of Heidelberg, Germany
No information available.
No information available
Received Date: 07.03.2013
Accepted Date: 22.06.2013
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ABSTRACT

PURPOSE

We aimed to determine the comparability of real-time tissue elastography (RTE) and transient elastography (TE) in pediatric patients with liver diseases.

MATERIALS AND METHODS

RTE was performed on the Elasticity QA Phantom Model 049 (Computerized Imaging Reference Systems Company Inc., Norfolk, Virginia, USA), which has five areas with different levels of stiffness. RTE measurements of relative stiffness (MEAN [mean value of tissue elasticity], AREA [% of blue color-coded stiffer tissue]) in the phantom were compared with the phantom stiffness specified in kPa (measurement unit of TE). RTE and TE were performed on 147 pediatric patients with various liver diseases. A total of 109 measurements were valid. The participants had following diseases: metabolic liver disease (n=25), cystic fibrosis (n=20), hepatopathy of unknown origin (n=11), autoimmune hepatitis (n=12), Wilson’s disease (n=11), and various liver parenchyma alterations (n=30). Correlations between RTE and TE measurements in the patients were calculated. In addition, RTE was performed on a control group (n=30), and the RTE values between the patient and control groups were compared.

RESULTS

The RTE parameters showed good correlation in the phantom model with phantom stiffness (MEAN/kPa, r=-0.97; AREA/kPa, r=0.98). However, the correlation of RTE and TE was weak in the patient group (MEAN/kPa, r=-0.23; AREA/kPa, r=0.24). A significant difference was observed between the patient and control groups (MEAN, P = 5.32 e-7; AREA, P = 1.62 e-6).

CONCLUSION

In the phantom model, RTE was correlated with kPa, confirming the presumed comparability of the methods. However, there was no direct correlation between RTE and TE in patients with defined liver diseases under real clinical conditions.