E-ISSN: 1305-3612
    Repeated transcatheter arterial chemoembolization is safe for hepatocellular carcinoma in cirrhotic patients with transjugular intrahepatic portosystemic shunt
    PDF
    Cite
    Share
    Request
    Interventional Radiology - Original Article
    VOLUME: 20 ISSUE: 6
    P: 487-491
    November 2014

    Repeated transcatheter arterial chemoembolization is safe for hepatocellular carcinoma in cirrhotic patients with transjugular intrahepatic portosystemic shunt

    Diagn Interv Radiol 2014;20(6):487-491
    DOI: 10.5152/dir.2014.13493
    Zhu Wang
    Hailong Zhang
    He Zhao
    Xiaoze Wang
    Jiaywei Tsauo
    Xuefeng Luo
    Xiao Li
    1. Institution of Interventional Radiology, West China Hospital, Sichuan University, Sichuan, China; Department of Gastroenterology, West China Hospital Sichuan University, Sichuan, China
    2. Department of Gastroenterology, West China Hospital, Sichuan University, Sichuan, China.
    3. Institution of Interventional Radiology, West China Hospital, Sichuan University, Sichuan, China.
    No information available.
    No information available
    Received Date: 02.01.2014
    Accepted Date: 16.06.2014
    PDF
    Cite
    Share
    Request

    ABSTRACT

    PURPOSE

    We aimed to investigate the safety and long-term outcomes of repeated transcatheter arterial chemoembolization (TACE) in cirrhotic patients with transjugular intrahepatic portosystemic shunt (TIPS).

    METHODS

    Data of patients with hepatocellular carcinoma, who had previous TIPS implantation and received TACE between January 2010 and December 2012, were reviewed retrospectively. The primary outcome measure was liver function, which was represented by model for end-stage liver disease score, Child-Pugh-Turcotte score, serum total bilirubin, alanine aminotransferase, and aspartate aminotransferase. Changes in liver function before and after the initial TACE procedure and hepatobiliary severe adverse events (SAEs) were compared. Liver function following the initial TACE session was compared with that obtained in later TACE sessions. The secondary outcome measures were tumor response to multiple TACE sessions and survival.

    RESULTS

    Seventeen patients underwent at least two TACE sessions, while nine patients underwent at least three sessions during the follow-up period. There was no statistically significant difference between the liver function tests performed before and one-month after the TACE procedure. Grade 3 or 4 SAEs occurred in six (31.6 %) patients within one month. The one, two-, and three-year survival rates were 88%, 53%, and 32%, respectively. Tumor response of multiple TACE sessions was the only predictive risk factor of mortality (OR=4.40; P = 0.030; 95% CI, 1.15–16.85).

    CONCLUSION

    Our results suggest that repeated TACE is safe in selected patients with TIPS.

    References

    2024 ©️ Galenos Publishing House