E-ISSN: 1305-3612
Role of diffusion-weighted imaging for detecting bone marrow infiltration in skull in children with acute lymphoblastic leukemia
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Pediatric Radiology - Original Article
VOLUME: 22 ISSUE: 6
P: 580-586
November 2016

Role of diffusion-weighted imaging for detecting bone marrow infiltration in skull in children with acute lymphoblastic leukemia

Diagn Interv Radiol 2016;22(6):580-586
DOI: 10.5152/dir.2016.15167
Weiguo Cao 1
Changhong Liang 2
Yungan Gen 3
Chen Wang 4
Cailei Zhao 3
Longwei Sun 3
1. Graduate College, Southern Medical University, Guangdong General Hospital, Guangzhou, China; Department of Radiology, Shenzhen Children’s Hospital, Shenzhen, China
2. Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, China
3. Department of Radiology, Shenzhen Children’s Hospital, Shenzhen, China.
4. Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden
No information available.
No information available
Received Date: 06.05.2015
Accepted Date: 29.03.2016
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ABSTRACT

PURPOSE:

We aimed to determine whether diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) measurement can detect skull bone marrow infiltration in newly diagnosed acute lymphoblastic leukemia (ALL) children before therapy and normalization in complete remission after treatment.

METHODS:

Fifty-one newly diagnosed acute lymphoblastic leukemia (ALL) patients and 30 healthy age-matched subjects were included. Cranial magnetic resonance imaging (MRI) scans were reviewed, and skull marrow ADC values were compared before treatment and in complete remission after therapy.

RESULTS:

Skull marrow infiltration, manifested with abnormal DWI signals, was present in 37 patients (72.5%) before treatment. Of these, 23 (62.2%) showed scattered signal abnormalities and 14 (37.8%) showed a uniform abnormal signal pattern. Compared with the control group, ADC was significantly decreased in patients with ALL. DWI signal intensity and ADC normalized in patients with complete remission.

CONCLUSION:

DWI is a useful and noninvasive tool for detecting skull infiltration in ALL children before treatment and normalization at complete remission after therapy, and it is superior to conventional MRI in terms of conspicuity of these lesions. DWI could be used as an MRI biomarker for evaluation of treatment in ALL children.