E-ISSN: 1305-3612
Single voxel in vivo proton magnetic resonance spectroscopy of breast lesions: experience in 77 cases
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Breast Imaging - Original Article
VOLUME: 19 ISSUE: 3
P: 221-226
May 2013

Single voxel in vivo proton magnetic resonance spectroscopy of breast lesions: experience in 77 cases

Diagn Interv Radiol 2013;19(3):221-226
DOI: 10.5152/dir.2012.005
Işıl Başara, 1
Şebnem Örgüç, 2
Teoman Coşkun 3
1. Department of Radiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey
2. Departments of Radiology, Celal Bayar University School of Medicine, Manisa, Turkey
3. Departments of General Surgery, Celal Bayar University School of Medicine, Manisa, Turkey
No information available.
No information available
Received Date: 04.07.2012
Accepted Date: 27.09.2012
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ABSTRACT

PURPOSE

We aimed to determine the value of in vivo single voxel proton magnetic resonance spectroscopy (MRS) in characterizing breast lesions.

MATERIALS AND METHODS

Breast MRS was performed in 77 patients. Choline resonance peak at 3.2 parts per million (ppm) was defined positive when it was at least two times higher than baseline. MRS findings were compared with the final diagnosis of cases for two different values (3.23 and 3.28 ppm).

RESULTS

Thirty-one malignant and 13 benign lesions had choline peaks. Sensitivity was 84%, specificity was 64%. Positive likelihood ratio (LHR) was 2.32, negative LHR was 0.25. Twenty-two malignant and 5 benign lesions had a peak at 3.23 ppm. Nine malignant and 8 benign lesions had a peak at 3.28 ppm. When 3.23 ppm was accepted as positive; sensitivity, specificity, and positive and negative LHRs were 79%, 82%, 4.4, and 0.26, respectively.

CONCLUSION

MRS provides additional parameters on evaluation of breast lesions. However, MRS of breast has some false negative results, thus it is still insufficient in clinical diagnosis.