E-ISSN: 1305-3612
The effect of using different embolic agents on survival in transarterial chemoembolization of hepatocellular carcinoma: gelfoam versus polyvinyl alcohol
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Interventional Radiology - Original Article
VOLUME: 20 ISSUE: 4
P: 323-329
July 2014

The effect of using different embolic agents on survival in transarterial chemoembolization of hepatocellular carcinoma: gelfoam versus polyvinyl alcohol

Diagn Interv Radiol 2014;20(4):323-329
DOI: 10.5152/dir.2014.13462
Ali Koçyiğit 1
Oğuz Dicle 2
Yiğit Göktay 2
İbrahim Astarcıoğlu 3
1. Department of Radiology, Pamukkale University School of Medicine, Denizli, Turkey
2. Department of Radiology, Dokuz Eylül University School of Medicine, İzmir, Turkey
3. Department of General Surgery , Dokuz Eylül University School of Medicine, İzmir, Turkey
No information available.
No information available
Received Date: 18.11.2013
Accepted Date: 18.12.2013
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ABSTRACT

PURPOSE

We aimed to compare the effect of using different embolic agents such as gelfoam and polyvinyl alcohol (PVA) on survival, tumor response, and complications in transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) patients.

MATERIALS AND METHODS

We retrospectively reviewed the medical records of 38 inoperable HCC patients who underwent TACE between August 1998 and April 2007. A total of 50 TACE sessions were performed using PVA (n=18) or gelfoam particles (n=20), following the application of 60 mg doxorubicin with 10–20 mL lipiodol emulsion. The PVA and gelfoam groups were compared based on clinical, laboratory, and demographic variables. Survival rates were calculated starting from the first TACE session using the Kaplan-Meier analysis.

RESULTS

There was no significant difference between the survival rates of PVA and gelfoam groups (P = 0.235). Overall survival rates at 12, 24, 36, 48, and 60 months were 55%, 36%, 15%, 7%, and 5%, respectively. Tumor response, age, lipiodol accumulation type, number of HCC foci, complications, and serum alpha-fetoprotein level were significant factors for survival in all patients.

CONCLUSION

Use of gelfoam or PVA as the embolic agent did not have a significant impact on survival. Complete tumor response, intensive lipiodol accumulation in tumor, older age (>60 years), fewer (≤3) HCC foci, and low serum alpha-fetoprotein level (≤400 ng/mL) were found to improve cumulative survival significantly.