The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer
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Breast Imaging - Original Article
P: 448-453
November 2015

The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer

Diagn Interv Radiol 2015;21(6):448-453
1. Department of Radiology, Florence Nightingale Hospital, İstanbul, Turkey
2. Department of Oncology, İstanbul Bilim University, İstanbul, Turkey
3. Department of Radiation Oncology, Florence Nightingale Hospital, İstanbul, Turkey
4. Department of General Surgery, Florence Nightingale Hospital, İstanbul, Turkey
5. Department of Physical Therapy and Rehabilitation, İstanbul Bilim University, İstanbul, Turkey
No information available.
No information available
Received Date: 29.11.2014
Accepted Date: 27.05.2015
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ABSTRACT

PURPOSE

The correlation between imaging findings and pathologic characteristics of tumors may provide information for diagnosis and treatment of cancer. The aim of this study is to determine whether ultrasound features of breast cancer are associated with molecular subtype, histologic grade, and hormone receptor status, as well as assess the predictive value of these features.

METHODS

A total of 201 consecutive invasive breast cancer patients were reviewed from the database according to the Breast Imaging and Reporting Data System (BI-RADS). Tumor margins were classified as circumscribed and noncircumscribed. Noncircumscribed group was divided into indistinct, spiculated, angular, and microlobulated. The posterior acoustic features were divided into four categories: shadowing, enhancement, no change, and mixed pattern.

RESULTS

Tumors with posterior shadowing were more likely to be of nontriple negative subtype (odds ratio [OR], 7.42; 95% CI, 2.10–24.99; P = 0.002), low histologic grade (grade 1 or 2 vs. grade 3: OR, 2.42; 95% CI, 1.34–4.35; P = 0.003) and having at least one positive receptor (OR, 3.36; 95% CI, 1.55–7.26; P = 0.002). Tumors with circumscribed margins were more often triple-negative subtype (OR, 6.72; 95% CI, 2.56–17.65; P < 0.001), high grade (grade 3 vs. grade 1 or 2: OR, 5.42; 95% CI, 2.66–11.00; P < 0.001) and hormone receptor negative (OR, 4.87; 95% CI, 2.37–9.99; P < 0.001).

CONCLUSION

Sonographic features are strongly associated with molecular subtype, histologic grade, and hormone receptor status of the tumor. These findings may separate triple-negative breast cancer from other molecular subtypes.