Diagnostic and Interventional Radiology
Modality-based (US, CT, MRI, PET-CT) Imaging - Original Article

A comparison study of dual-energy spectral CT and 18F-FDG PET/CT in primary tumors and lymph nodes of lung cancer

1.

Department of Nuclear Medicine Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey

2.

Department of Radiology, Ankara University School of Medicine, Ibni Sina Hospital, Ankara, Turkey

3.

Department of Radiation Oncology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey

4.

Department of Radiology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey

5.

Department of Biochemistry, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey

Diagn Interv Radiol 2021; 27: 275-282
DOI: 10.5152/dir.2021.20016
Read: 174 Downloads: 82 Published: 14 May 2020

PURPOSE 
We aimed to investigate whether there is a correlation between dual-energy spectral computed tomography (DESCT) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters in primary tumor and metastatic lymph nodes in patients with newly diagnosed lung cancer.

METHODS
Primary tumor and metastatic lymph nodes of 68 patients diagnosed with lung cancer were evaluated retrospectively with 18F-FDG PET/CT and DESCT imaging. The histologic subtypes were adenocarcinoma (n=29), squamous cell carcinoma (SCC) (n=26), small cell lung cancer (SCLC) (n=11), and large cell neuroendocrine cancer (LCNEC) (n=2). In terms of PET parameters, SUVmax, SUVmean, SULmax, SULmean, SULpeak, and normalized SUL values were obtained for primary tumors and metastatic lymph nodes. In terms of DESCT parameters, maximum and mean iodine content (IC), normalized IC values, iodine enhancement (IE) and normalized IE values were calculated. 

RESULTS
We found no correlation between DESCT and 18F-FDG PET/CT parameters in primary tumors and metastatic lymph nodes. In addition, no correlation was found in the analysis performed in any of the histologic subgroups. In patients with a primary tumor <3 cm, there was a moderate negative correlation between the parameters SUVmax-ICmax (r= -0.456, p = 0.043), 
SUVmean-ICmax (r= -0.464, p = 0.039) SULmean-ICmax (r= -0.497, p = 0.026), SUVmax-ICmean (r= -0.527, p = 0.020), SULmean-ICmean (r= -0.499, p = 0.025), and SULpeak-ICmean (r= -0.488, p = 0.029).

CONCLUSION
We consider that DESCT and 18F-FDG PET/CT indicate different characteristics of the tumors and should not supersede each other.

You may cite this article as: Kupik O, Metin Y, Eren G, Orhan Metin N, Arpa M. A comparison study of dual-energy spectral CT and 18F-FDG PET/CT in primary tumors and lymph nodes of lung cancer. Diagn Interv Radiol 2021; 27: 275–282

Files
EISSN 1305-3612