Diagnostic and Interventional Radiology
Interventional Radiology - Case Report 2016

A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization

1.

School of Life and Health Sciences, Adikavi Nannaya University, Rajahmundry/AP, India

2.

Department of Radiology, Chung-Ang University College of Medicine, Seoul, Republic of Korea

3.

Department of Orthopedic Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea

4.

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea

5.

Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea

6.

Biologics Research Division, Korea Food and Drug Administration, Chungbuk, Republic of Korea

Diagn Interv Radiol 2013; 19: 76-80
DOI: 10.4261/1305-3825.DIR.5877-12.2
Read: 509 Downloads: 255 Published: 03 September 2019

Abstract

ABSTRACT 
A 61-year-old male patient with atherosclerotic critical limb ischemia in the left leg underwent stent insertion into the left superficial femoral artery. Stenting procedures improved Rutherford grade from III-5 to II-4. Granulocyte colony-stimulating factor stimulated the production of white blood cells over four-fold and mononuclear cells (MNCs) 1.5-fold in the whole blood. Transplantation of 7.9×10 9 autologous MNCs into the left femoral artery rapidly decreased the leg pain intensity, with further improvement of Rutherford grades from II-4 to 0-0 without any side effects. In the four-year follow-up, significant improvement was found in terms of ankle brachial index, from nondetectable to 0.67, and peak systolic velocity, from 14.8 to 36.1 cm/s. Limb salvage and decreased resting pain were the notable outcomes of the treatment.

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