Diagnostic and Interventional Radiology
Chest Imaging - Original Article

Contrast enhanced CT versus integrated PET-CT in pre-operative nodal staging of non-small cell lung cancer


Department of Radiology, Ege University School of Medicine, Izmir, Turkey


Departments of Radiology, Ege University School of Medicine, İzmir, Turkey


Clinic of Nuclear Medicine, Ege Sağlık Hospital, İzmir, Turkey

Diagn Interv Radiol 2012; 18: 435-440
DOI: 10.4261/1305-3825.DIR.5100-11.2
Read: 1000 Downloads: 852 Published: 03 September 2019


The purpose of this study was to retrospectively evaluate the effectiveness of integrated positron emission tomographycomputed tomography (PET-CT) in comparison with contrast enhanced CT (CE-CT) in pre-operative staging of non-small cell lung cancer (NSCLC) by using surgical and pathological findings as the reference standard.


From August 2008 to August 2009, 57 consecutive patients (50 males and 7 females; mean age, 59 years; range, 38–79 years) with NSCLC underwent conventional pre-operative lung cancer staging using clinical data and CE-CT of the chest, and integrated whole-body fluorine-18 fluorodeoxyglucose PET-CT studies. Histopathological results served as the reference standard.


Forty-eight of the 57 patients (84%) had no lymph node involvement (N0), five (9%) were found to have N1 disease, and four (7%) had N2 disease. There was a significant difference between CE-CT and PET-CT for nodal staging of N0 disease (P < 0.05). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of hilar and mediastinal lymph node staging were 56%, 73%, 28%, 90%, and 70%, with CE-CT, respectively; and 78%, 92%, 64%, 96%, and 89% with PET-CT, respectively.


Integrated PET-CT is more accurate than CE-CT for lymph node staging in NSCLC.

EISSN 1305-3612