Diagnostic and Interventional Radiology
Chest Imaging - Original Article

Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer

1.

Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

2.

Department of Neoplasms and Interventional Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3.

Department of Interventional Radiology, Changzheng Hospital, the Second Military Medical University, Shanghai, China

Diagn Interv Radiol 2021; 27: 476-481
DOI: 10.5152/dir.2021.20332
Read: 509 Downloads: 34 Published: 08 March 2021

PURPOSE 
We aimed to evaluate whether bronchial artery can supply a percutaneously inoculated canine transmissible venereal tumor (CTVT) in a lung tumor model. 

METHODS
Fresh CTVT tissue blocks were percutaneously inoculated into unilateral or bilateral lungs of six immunosuppressed dogs at the mid zone of the middle or lower lobe. Tumor growth was monitored by computed tomography (CT). Ten weeks after inoculation, pulmonary arterial digital subtraction angiography (DSA), bronchial arterial DSA, transpulmonary arterial contrast-enhanced multislice CT, transbronchial arterial contrast-enhanced multislice CT (BA-MSCT), and transpulmonary arterial lipiodol multislice CT were performed. 

RESULTS
Tumor growth was seen in all 10 inoculated sites, with a maximum diameter of 2.734±0.138 cm at 10th week. Bronchial arterial blood supply was evident in 9 nodules on DSA, and was equivocal in one which was later demonstrated on BA-MSCT. No obvious pulmonary arterial blood supply was observed in any of  the nodules. Lipiodol deposition was displayed in two of the small distant metastases, which indicated that pulmonary artery was involved in the supply of the metastases. 

CONCLUSION
Our results demonstrated bronchial arterial blood supply in this new lung cancer model. This model may be used in further research on transbronchial arterial intervention for lung cancer.

You may cite this article as: Sun Z, An X, Liu H, Dong W, Xiao X. Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer. Diagn Interv Radiol 2021; 27:476-481
 

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