Diagnostic and Interventional Radiology
Musculoskeletal Imaging - Original Article

Fat fraction quantification of lumbar spine: comparison the value of T1-weighted two-point dixon and single-voxel magnetic resonance spectroscopy in diagnosis of multiple myeloma

1.

Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

2.

Department of hematology,Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

3.

Scientific Clinical Specialist, Siemens Healthcare Ltd., Beijing, China

Diagn Interv Radiol 2020; 1: -
Read: 54 Published: 02 January 2020

PURPOSE: To investigate the value of T1-weighted two-point Dixon technique and single-voxel Magnetic Resonance Spectroscopy (MRS) in diagnosis of multiple myeloma (MM) through quantifying fat content of vertebral marrow.

METHODS: Thirty MM patients and thirty healthy volunteers were enrolled and underwent the T1-weighted two-point Dixon and single voxel MRS imaging. The fat fraction map (FFM) was reconstructed from Dixon images using the equation FFM = Lip/In where Lip represented fat maps and In represented in-phase images. The fat fraction of MRS (MRS-FF) was calculated by using the integral area of lip peak divided by the sum of integral area of lip peak and water peak.

RESULTS: FF values measured by the Dixon and MRS were significantly decreased in the MM patients (45.99 ± 3.39 % and 47.63 ± 4.38 %) than healthy volunteers (64.43 ± 0.96 % and 76.22 ± 1.91 %) (all P < 0.001). FF values measured by Dixon were significantly positively correlated to that measured by MRS in MM (r = 0.837, P < 0.001) and normal group (r = 0.735, P < 0.001) respectively. ROC analysis showed that there was no significance difference between area under the curve of Dixon ([0.878 ± 0.047, (0.785 to 0.971)] (optimal cutoff values: 56.35) (normal vs MM)) and MRS ([0.883 ± 0.047, (0.791 to 0.974)]) (optimal cutoff values: 61.00) (normal vs MM)). ROC analysis demonstrated that the ability of Dixon to differentiate MM group from normal group exhibited equivalent performance to single-voxel MRS.

CONCLUSION: Regarding detection of fat contents in vertebral bone, T1-weighted two-point Dixon exhibited equivalent performance to single-voxel MRS in diagnosis of multiple myeloma. Moreover, two-point Dixon is a more convenient and stable technique for assessing bone marrow changes in MM patients than single-voxel MRS.

EISSN 1305-3612