Diagnostic and Interventional Radiology
Abdominal Imaging - Original Article

Is quantitative diffusion-weighted MRI a reliable method in the assessment of the inflammatory activity in ulcerative colitis?

1.

From the Department of Radiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey

2.

Departments of Gastroenterology, Bakırköy Training and Research Hospital, İstanbul, Turkey

3.

Departments of Internal Medicine, Bakırköy Training and Research Hospital, İstanbul, Turkey

4.

Radiology Clinic, Bakırköy Training and Research Hospital, İstanbul, Turkey

5.

Department of Gastroenterology, Kartal Training and Research Hospital, İstanbul, Turkey

6.

Departments of Gastroenterology, Haseki Training and Research Hospital, İstanbul, Turkey

Diagn Interv Radiol 2010; 16: 293-298
DOI: 10.4261/1305-3825.DIR.2989-09.1
Read: 673 Downloads: 373 Published: 03 September 2019

Abstract

PURPOSE
We investigated the relationship between the apparent diffusion coefficient (ADC) values of the colonic wall and the pathologic pericolonic lymph nodes (PCLNs) and inflammatory activity in ulcerative colitis patients by diffusion-weighted magnetic resonance imaging (DW-MRI).

 

MATERIALS AND METHODS
A total of 28 ulcerative colitis patients (9 endoscopically active, 10 subacute and 9 in remission) were evaluated by DW-MRI with 0, 500 and 1000 s/mm2 b-values. The ADC values of the rectum and sigmoid colon walls and the adjacent PCLNs were obtained for quantitative analysis. The DW-MRI findings were compared to the disease activity.

 

RESULTS
The ADC values of the sigmoid colon were similar in patients with active, subacute and remissive ulcerative colitis (P = 0.472). The ADC values of the rectum were different (P = 0.009) between patients in the active (1.08 ± 0.14×10¯³ mm2/s) and subacute phases (1.13 ± 0.23×10¯³ mm2/s) of disease and those in remission (1.29 ± 0.17×10¯³ mm2/s). The ADC values of the PCLNs (P = 0.899) did not differ with respect to disease activity.

 

CONCLUSION
DW-MRI is useful in identifying disease activity in ulcerative colitis patients, especially with respect to the rectum. The ADC values of the rectum increase during remission and decrease in patients with active distal colitis. The ADC values of the PCLNs were not useful in determining disease activity.

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EISSN 1305-3612