Diagnostic and Interventional Radiology
Interventional Radiology - Original Article

Managing occluded stents in biliary obstruction using radiofrequency ablation combined with 125I-strand brachytherapy


Department of interventional radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Diagn Interv Radiol 2021; 27: 79-84
DOI: 10.5152/dir.2020.20143
Read: 366 Downloads: 233 Published: 18 May 2020


We aimed to assess the effectiveness of percutaneous radiofrequency ablation (PRFA) combined with iodine-125 (125I) seed strand brachytherapy (125I-BT) for treatment of occluded biliary stents.



From November 2015 to September 2017, 13 consecutive patients with occluded biliary metal stents, implanted for malignant obstruction, underwent PRFA combined with 125I-BT to reopen the bile duct. Data included clinical and technical success, stent patency, complications, and overall survival.



The clinical and technical success rates were both 100%. One month after treatment, the total serum bilirubin level had decreased significantly (P < 0.001). Early complications of cholangitis or hemobilia were experienced by one patient each. Three patients (23.1%) had late complications, including two cases of cholangitis and one case of cholecystitis. During the mean follow-up of 233±82.9 days (range, 88–365 days), the stent patency time was 239±26.5 days (95% CI, 187–291 days), and the 6-month stent patency rate was 68.4%. Five patents died; the mean survival time was 298±30.1 days (95% CI, 239–358 days). The 6-month survival rate was 83%.



PRFA therapy combined with 125I-BT is feasible and safe for patients with occluded metal stents placed for malignant biliary obstruction. Nevertheless, randomized controlled trails are needed to confirm the effectiveness of this new approach.


You may cite this article as: Yao Y, Jiao D, Lei Q, Li Z, Wang Y, Han X. Managing occluded stents in biliary obstruction using radiofrequency ablation combined with 125I–strand brachytherapy. Diagn Interv Radiol 2021; 27: 79–84.

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