Diagnostic and Interventional Radiology
Neuroradiology - Case Report 2016

MRI of recurrent isolated cerebral Whipple's disease

1.

Department of Radiology, Başkent University School of Medicine, Ankara, Turkey

2.

Department of Radiology, Başkent University School of Medicine, Ankara, Turkey

3.

Departments of Pathology, Başkent University School of Medicine, Ankara, Turkey

4.

Departments of Radiology, Başkent University School of Medicine, Ankara, Turkey

Diagn Interv Radiol 2010; 16: 112-115
DOI: 10.4261/1305-3825.DIR.1830-08.1
Read: 660 Downloads: 415 Published: 03 September 2019

Abstract

 

Whipple's disease is a rare systemic bacterial infection, characterized predominantly by gastrointestinal symptoms. Neurological symptoms are frequent in the course of the disease; however, a purely neurological presentation is uncommon. Diagnosis is confirmed with biopsy and polymerase chain reaction studies. Magnetic resonance imaging (MRI) findings vary, most commonly showing increased signal intensity on T2-weighted images. Contrast-enhanced images and diffusion- weighted imaging are useful to demonstrate meningeal enhancement and any accompanying infarcts. Brain biopsy is often performed, and MRI is crucial to guide the biopsy. Cerebral Whipple's disease is a long-lasting infection requiring long-term follow-up of these patients. MRI should be performed to detect any potential recurrence. We present a case of recurrent isolated cerebral Whipple's disease in a 68-yearold man with atypical presentation and MRI findings.
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EISSN 1305-3612