Diagnostic and Interventional Radiology
Interventional Radiology - Original Article

MRI traceability of superparamagnetic iron oxide nanoparticle-embedded chitosan microspheres as an embolic material in rabbit uterus


Department of Radiology and Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Republic of Korea.


Department of Radiology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.


College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.


Department of Maritime Medicine, Maritime Medical Center, Jinhae, Republic of Korea


Department of Radiology, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, Republic of Korea.

Diagn Interv Radiol 2015; 21: 47-53
DOI: 10.5152/dir.2014.14015
Read: 519 Downloads: 204 Published: 03 September 2019



We aimed to compare polyvinyl alcohol (PVA) particles with calibrated superparamagnetic iron oxide (SPIO) nanoparticle-loaded chitosan microspheres in a rabbit model, specifically regarding the relative distribution of embolic agents within the uterus based on magnetic resonance imaging (MRI) and pathological evaluation.



Twelve New Zealand white rabbits underwent uterine artery embolization using either standard PVA particles (45–150 µm or 350–500 µm) or calibrated SPIO-embedded chitosan microspheres (45–150 µm or 300–500 µm). MRI and histopathological findings were compared one week after embolization.



Calibrated SPIO-loaded chitosan microspheres 45–150 µm in size were detected on T2-weighted images. On histological analysis, calibrated SPIO-embedded chitosan microspheres were found in both myometrium and endometrium, whereas  PVA particles were found only in the perimyometrium or extrauterine fat pads. A proportional relationship was noted between the calibrated SPIO-embedded chitosan microsphere size and the size of the occluded artery.



Calibrated SPIO-embedded chitosan microspheres induced greater segmental arterial occlusion than PVA particles and showed great potential as a new embolic material. SPIO-embedded chitosan microspheres can be used to follow distribution of embolic particles through MRI studies.

EISSN 1305-3612