Diagnostic and Interventional Radiology
Interventional Radiology - Original Article

Radiofrequency ablation of liver metastases from cancer of unknown primary site


Departments of Radiology, Red Cross Hospital Athens, Greece


Departments of Radiology, Alexandra General Hospital Athens, Greece


Departments of Radiology, Red Cross Hospital Athens, Greece


Department of Radiology, Red Cross Hospital, Athens, Greece


Departments of Radiology, Sotiria Hospital Athens, Greece

Diagn Interv Radiol 2009; 15: 297-302
DOI: 10.4261/1305-3825.DIR.1714-08.1
Read: 940 Downloads: 635 Published: 03 September 2019


This retrospective study was performed to review the efficacy of local radiofrequency ablation (RFA) in all the management of liver cancer of unknown primary site (CUP), and to identify possible prognostic features and complications that affect the efficacy of this treatment on survival.


From April 2003 to December 2007, 22 patients (15 men, 7 women) with a total of 36 liver metastasis of CUP and poor response to prior systemic chemotherapy were treated with computed tomography-guided RFA. The median age of patients was 66 years. All patients (22/22) had 1-, 3-, and 6- month follow-up and 8/22 of them had a 12-month followup.


The overall median survival of all 22 patients was 10.9 months. Survival was better in patients with lesions 3 cm or smaller. No severe complications, including local seeding, were occured.


Our study revealed that RFA appears to be an effective, safe and relatively simple alternative procedure for the local ablation of these lesions. These results are more encouraging for lesions 3 cm or smaller, all of which were successfully treated, as proved by the imaging criteria and the statistical analysis. Further prospective trials are needed to determine whether RFA should be proposed for standard protocols.

EISSN 1305-3612