Diagnostic and Interventional Radiology
Interventional Radiology - Review

Radiomics and circulating tumor cells: personalized care in hepatocellular carcinoma?


West Middlesex University Hospital, London, UK


Department of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA


Division of Vascular Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Diagn Interv Radiol 2015; 21: 78-84
DOI: 10.5152/dir.2014.14237
Read: 922 Downloads: 295 Published: 03 September 2019


Personalized care in oncology is expected to significantly improve morbidity and mortality, facilitated by our increasing understanding of the molecular mechanisms driving tumors and the ability to target those drivers. Hepatocellular carcinoma has a very high mortality to incidence ratio despite localized disease being curable, emphasizing the importance of early diagnosis. Radiomics, the use of imaging technology to extrapolate molecular tumor data, and the detection of circulating tumor cells (CTCs) are two new technologies that could be incorporated into the clinical setting with relative ease. Here we discuss the molecular mechanisms leading to the development of hepatocellular carcinoma focusing on the latest developments in liver magnetic resonance imaging, CTC, and radiomic technology and their potential to improve diagnosis, staging, and therapy. 

EISSN 1305-3612