Diagnostic and Interventional Radiology
Abdominal Imaging - Original Article

Study of the influence of tube voltage, tube current and newer iterative reconstruction algorithm in computed tomography perfusion imaging in rabbit liver VX2 tumors


Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

Diagn Interv Radiol 2020; 1: -
Read: 232 Published: 12 November 2019

PURPOSE: To explore the influence of tube voltage, current and iterative reconstruction (IR) in CT perfusion imaging (CTPI) and to compare CTPI parameters with microvessel density (MVD).

METHODS: Hepatic CTPI with three CTPI protocols (A: tube voltage/current 80kV/40mAs; B: tube voltage/current 80kV/80mAs; C: tube voltage/current 100kV/80mAs) were performed in 25 rabbit liver VX2 tumor models, and filtered back projection (FBP) and IR were used for reconstruction of raw data. Hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP), total perfusion (TP), hepatic arterial perfusion index (HPI), Blood flow (BF) and blood volume (BV) of VX2 tumor and normal hepatic parenchyma were measured. Image noise, signal to noise ratio (SNR) and contrast to noise ratio (CNR) were quantified and radiation dose was recorded. MVD was counted with CD34 stain and compared with CTPI parameters.

RESULTS: The highest radiation dose was found in protocol C, followed by protocol B and A. IR lowered image noise and improved SNR and CNR among three protocols. There was no statistical difference of HAP, HPP, TP, HPI, BF and BV of VX2 tumor and normal hepatic parenchyma among three protocols (P > 0.05) with FBP or IR reconstruction, and no statistical difference between IR and FBP reconstruction (P > 0.05) in each protocol. There was best correlation between MVD and HAP, TP, BF with positive linear relationship, especially HAP; no or poor correlation between MVD and HPI, BV of VX2 tumor.

CONCLUSION: CTPI parameters are not affected by tube voltage, current and reconstruction algorithm; HAP can best reflect MVD, but no correlation exists between BV and MVD.

EISSN 1305-3612