Diagnostic and Interventional Radiology
Interventional Radiology - Original Article

Volumetric MRI-guided, high-intensity focused ultrasound ablation of uterine leiomyomas: ASEAN preliminary experience

1.

Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia;Department of Radiology, Hospital Universiti Sains Malaysia, USM 16150 Kubang Kerian, Kelantan, Malaysia

2.

Department of Radiology, Pham Ngoc Thach University School of Medicine, Ho Chi Minh City, Vietnam

3.

Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

Diagn Interv Radiol 2020; 26: 207-215
DOI: 10.5152/dir.2019.19157
Read: 198 Downloads: 86 Published: 03 September 2019

PURPOSE

We sought to present our preliminary experience on the effectiveness and safety of magnetic resonance imaging (MRI)-guided, high-intensity focused ultrasound (HIFU) therapy using a volumetric ablation technique in the treatment of Association of Asian Nations (ASEAN) patients with symptomatic uterine leiomyomas.

 

METHODS

This study included 33 women who underwent HIFU treatment. Tissue characteristics of leiomyomas were assessed based on T2- and T1-weighted MRI. The immediate nonperfused volume (NPV) ratio and the treatment effectiveness of MRI-guided HIFU on the basis of the degrees of volume reduction and improvement in transformed symptom severity score (SSS) were assessed.

 

RESULTS

The median immediate NPV ratio was 89.8%. Additionally, the median acoustic sonication power and HIFU treatment durations were 150 W and 125 min, respectively. At six-month follow-up, the median leiomyoma volume had decreased from 139 mL at baseline to 84 mL and the median transformed SSS had decreased from 56.2 at baseline to 18.8. No major adverse events were observed.

 

CONCLUSION

The preliminary results demonstrated that volumetric MRI-guided HIFU therapy for the treatment of symptomatic leiomyomas in ASEAN patients appears to be clinically acceptable with regard to treatment effectiveness and safety.

 

You may cite this article as: Keserci B, Duc NM, Nadarajan C, et al. Volumetric MRI-guided, high-intensity focused ultrasound ablation of uterine leiomyomas: ASEAN preliminary experience. Diagn Interv Radiol 2020; 26:207–215.

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