E-ISSN 1305-3612
Interventional Radiology - Original Article
Volumetric magnetic resonance imaging–guided, high-intensity focused ultrasound ablation of uterine leiomyomas: ASEAN preliminary experience
1 Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia;Department of Radiology, Hospital Universiti Sains Malaysia, USM 16150 Kubang Kerian, Kelantan, Malaysia  
2 Department of Radiology, Pham Ngoc Thach University School of Medicine, Ho Chi Minh City, Vietnam  
3 Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam  
Diagn Interv Radiol ; : -



PURPOSE: We sought to present our preliminary experience on the efficacy and safety of magnetic resonance imaging (MRI)–guided, high-intensity focused ultrasound (HIFU) therapy using a volumetric ablation technique in the treatment Association of Asian Nations (ASEAN) patients with symptomatic uterine leiomyomas.


METHODS: This study included 33 women who underwent HIFU treatment. Tissue characteristics of leiomyomas were assessed based on T2- and T1-weighted MRI. The immediate nonperfused volume (NPV) ratio and the treatment efficacy of MRI-guided HIFU on the basis of the degrees of volume reduction and improvement in transformed symptom severity score (SSS), respectively, were assessed.


RESULTS: The median immediate NPV ratio was 89.8%. Additionally, the median acoustic sonication power and HIFU treatment durations were 150 W and 125 min, respectively. At the six-month follow-up point, the median leiomyoma volume had decreased from 139 mL at baseline to 84 mL and the median transformed SSS had decreased from 56.2 at baseline to 18.8. No major adverse events were observed.


CONCLUSION: The preliminary results demonstrated that volumetric MRI-guided HIFU therapy for the treatment of symptomatic leiomyomas in ASEAN patients appears to be clinically acceptable with regard to treatment efficacy and safety.

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