E-ISSN 1305-3612
Interventional Radiology - Original Article
The interaction between irreversible electroporation therapy (IRE) and embolisation material using a validated vegetal model: an experimental study
1 Department of Radiology, The Alfred Hospital, Victoria, Australia  
2 Department of Pathology, The Alfred Hospital, Victoria, Australia  
3 Department of Pathology, Sunshine Hospital, Victoria, Australia  
4 -Department of Radiology, The Alfred Hospital, Victoria, Australia;Department of Surgery, Monash University, Melbourne, Australia  
Diagn Interv Radiol ; : -

Abstract

PURPOSE: Irreversible electroporation (IRE) is a non-thermal tumour ablation technique that induces cell apoptosis while preserving extracellular architecture. Surgical clips and embolic agents may lie adjacent to, or within, the target lesion. It is unknown to date if IRE causes degradation to the embolic agents or surgical clips that may have adverse effects to patients.We aim to examine the 1) effects of the IRE on the morphology of various embolic agents and 2) effects of these agents to the ablation field using a previously validated vegetal model.

 

METHODS: Metallic surgical clips and various metallic and non-metallic embolic agents were inserted within the centre of the tuber ablation field. Additionally, clips were inserted on the edge and outside the ablation field. One tuber was ablated as a control. Ablation settings were based on previous published experiments. Tubers were imaged with MRI 18-24 hours after ablation and the ablated field dimensions were measured.Non-metallic embolic agents were examined microscopically by the pathologist.

 

RESULTS: Non-metallic agents did not affect the ablation pattern. Metallic implants, however, caused arcing of the ablation margins. There was no macroscopic or microscopic degradation to all agents after IRE.

 

CONCLUSION: The ablation zone arced in the presence of surgical clips at the edge or outside the ablation margins, therefore nearby critical structures may be susceptible to the effects of IRE. Furthermore, there was no physical degradation of the embolic agents or surgical clips, and this may have importance when considering IRE ablation of previously embolised lesions in vivo.

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