E-ISSN 1305-3612
Interventional Radiology - Original Article
Multiple imaging modalities guided radiofrequency ablation combined with transarterial chemoembolization for hepatocellular carcinomas in special locations
1 Shanghai Public Health Clinical Center, Fudan University, Shanghai, China  
2 Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China  
Diagn Interv Radiol ; : -

Abstract

 

PURPOSE: We aimed to evaluate safety and effects of radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) guided by multiple imaging modalities for hepatocellular carcinomas (HCC) in special locations compared with those in conventional ones.

 

METHODS: 122 HCC patients were enrolled, including 85 (69.7%) patients in conventional locations and 37 (30.3%) in special locations. The clinical data, overall survival (OS), progression free survival (PFS) and procedure-related adverse events were analyzed.

 

RESULTS: RFA combined with TACE was successfully performed in all patients. Three (2.5%) complications occurred, with no significant (P = 0.218) difference between the conventional (1 or 1.2%) and special (2 or 5.4%) locations. The tumor complete necrosis rate was not significantly (P = 0.353) different between the conventional (73 or 85.9%) and special location (34 or 91.9%) on one-month imaging. Followed up for 3-48 months, the PFS was 17 months in the conventional but 14 months in the special location, and the tumor PFS rate was 68.1(%) in the conventional location, not significantly (P = 0.741) different from 59.1(%) in the special location at 1 year. The OS was 28 months in the conventional but 32 months in the special location. The cumulative one- and two-year OS rates were 89.9(%) and 63.3(%), respectively, for the conventional location, not significantly (P = 0.273) different from 96.3(%) and 65(%) for the special location. Age (P = 0.043) and tumor size (P < 0.001) were significant prognostic factors for OS, and tumor size (P < 0.001) was the only significant prognostic factor for PFS.

 

CONCLUSION: Radiofrequency ablation guided by multiple imaging modalities combined with transarterial chemoembolization may be safe and effective for treating hepatocellular carcinomas in special locations.

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