ISSN 1305-3825 | E-ISSN 1305-3612
Chest Imaging - Original Article
Evaluation of anterior mediastinal solid tumors by CT perfusion: a preliminary study
1 Department of Radiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey  
2 Department of Thoracic Surgery, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey  
3 Department of Pathology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey  
Diagn Interv Radiol 2017; 23: 10-14
DOI: 10.5152/dir.2016.16093
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Abstract

PURPOSEWe aimed to assess the role of computed tomography (CT) perfusion in differentiation of thymoma from thymic hyperplasia, lymphoma, thymic carcinoma, and lung cancer invading anterior mediastinum.

 

METHODSIn this study, 25 patients with an anterior mediastinal lesion underwent CT perfusion imaging from January 2015 to February 2016. Diagnoses included thymoma (n=7), thymic hyperplasia (n=8), lymphoma (n=4), thymic carcinoma (n=3), and invasive lung cancer (n=3). Lymphoma, thymic carcinoma, and lung cancer were grouped as malignant tumors for statistical analysis. Values for blood flow, blood volume, and permeability surface were measured in CT perfusion.

 

RESULTSBlood flow and blood volume values were higher in thymoma in comparison to thymic hyperplasia; however, the difference was not statistically significant. Blood volume values were significantly higher in thymoma (mean, 11.4 mL/100 mL; range, 5.2–20.2 mL/100 mL) compared with lymphoma (mean, 5.3 mL/100 mL; range, 2.5–7.2 mL/100 mL) (P = 0.023). Blood flow and blood volume values were significantly higher in thymoma compared with non-thymoma malignant tumors (P = 0.025).

 

CONCLUSIONCT perfusion is helpful in differentiating thymoma from non-thymoma malignancies including lymphoma, thymic carcinoma, and invasive lung cancer involving the anterior mediastinum.

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