E-ISSN 1305-3612
1 Department of Radiology, Seoul St. Mary’s Hospital, The Catholic University of Korea School of Medicine, Seoul, Republic of Korea  
Diagn Interv Radiol ; : -



PURPOSE: To evaluate the diagnostic efficacy of fusion imaging of unenhanced and arterial phase contrast-enhanced CBCT by comparing with MDCT in detection of viable HCC in patients who have been previously treated with TACE.


METHODS: In this retrospective study, a total of 173 tumors in 33 known HCC patients (21 men, 12 women; mean age, 64±7.6 years; mean tumor size, 2.15±1.70 cm) who had been previously treated with TACE and underwent additional session of TACE were included. The sensitivity and positive predictive values of pre-procedural MDCT and fusion CBCT for detection of viable tumor were analyzed with follow-up MDCT images performed 3-4 weeks after TACE as reference standard.


RESULTS: A total of 141 remote and 32 marginal viable tumors were included. The sensitivities for detection of remote, marginal, and total viable tumors of MDCT were 80.9%, 68.8%, and 78.6%, and of fusion CBCT are 96.5%, 96.9%, 96.5%, respectively. The positive predictive values for detection of remote, marginal, and total viable tumors of MDCT were 95.0%, 78.6%, and 95.8%, and of fusion CBCT were 97.1%, 88.6%, 97.7%, respectively. Fusion CBCT showed statistically higher sensitivity and positive predictive value for detection of viable tumors (P < 0.001).


CONCLUSION: The diagnostic performance of fusion imaging of unenhanced and contrast-enhanced arterial phase CBCT was superior to MDCT for detection of viable HCCs.

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