E-ISSN 1305-3612
Unspecified - Original Article
Subsequent cooling-circulation after radiofrequency and microwave ablation avoids secondary indirect damage induced by residual thermal energy
Xinyi Shi 1 ,  
Hong Pan 1 ,  
Han Ge 1 ,  
Li Li 1 ,  
Yi Xu 2 ,  
Hui Xie 1 ,  
1 Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China  
2 Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China  
Diagn Interv Radiol ; : -
DOI: 10.5152/dir.2019.17455
Abstract

PURPOSE

We aimed to investigate the exact role of residual thermal energy following microwave ablation (MWA) and radiofrequency ablation (RFA) at the final ablation and transition zones and determine whether residual thermal energy could be dissipated by subsequent cooling-circulation.

 

METHODS

In an ex vivo study, MWA and RFA were performed on fresh porcine liver, and central and border temperatures were compared. In an in vivo study, MWA and RFA were performed to the livers of New Zealand white rabbits. Tissue samples were stained with α-NADH-diaphorase. The coagulation zones (NADH-negative) and transition zones (lightly NADH-stained) of different groups were compared at different time points.

 

RESULTS

In the ex vivo model, the residual thermal energy after MWA and RFA could be dispersed by subsequent cooling-circulation due to the temperature decreasing rapidly. In the in vivo study, the coagulation volume in the ablation group was larger than that in the cooling-circulation group (P < 0.05) 2 days after ablation. In the ablation group, the damaged zone (the transition zone plus the coagulation zone) on α-NADH-diaphorase-stained images increased rapidly within 2 hours after ablation and slowly reached the maximum on day 2. However, the damaged zones did not change significantly at the three time points observed in the cooling-circulation group.

 

CONCLUSION

The residual thermal energy in MWA and RFA induced secondary damage beyond the direct coagulation zone, and it could be dissipated by subsequent cooling-circulation, contributing to smaller ablation and transition zones.

 

You may cite this article as: Shi X, Pan H, Ge H, et al. Subsequent cooling-circulation after radiofrequency and microwave ablation avoids secondary indirect damage induced by residual thermal energy. Diagn Interv Radiol 2019; DOI 10.5152/dir.2019.17455.

Key Words
Authors
All
Author's Corner
Reviewer's Corner
Survey
Copyright © 2019 Turkish Society of Radiology | Latest Update: 10.05.2019