ISSN 1305-3825 | E-ISSN 1305-3612
Chest Imaging - Original Article
Multiparametric MRI in differentiating pulmonary artery sarcoma and pulmonary thromboembolism: a preliminary experience
1 Department of Radiology, Beijing Chaoyang Hospital of Capital Medical University, Beijing, China  
2 Department of Radiology, the second affiliated Hospital of Xi'an Medical College, Xi’an City,China  
3 Department of Clinical Pathology, Beijing Chaoyang Hospital of Capital Medical University, Beijing, China  
4 Respiratory Diseases Research Center, Beijing Chaoyang Hospital of Capital Medical University, Beijing, China  
5 Siemens MR Northeastern Collaboration Application Department, Siemens MRI Center, Beijing,China  
Diagn Interv Radiol 2017; 23: 15-21
DOI: 10.5152/dir.2016.15584
Abstract

PURPOSE: We aimed to define multiparametric magnetic resonance imaging (MRI) findings to differentiate between pulmonary artery sarcoma (PAS) and pulmonary thromboembolism (PTE).

 

METHODS: Eleven patients with suspected PTE were prospectively included to undergo pulmonary MRI before surgery or biopsy. MRI protocol included an unenhanced sequence, diffusion-weighted imaging (DWI, b=800 s/mm2) and a dynamic contrast-enhanced sequence. Morphologic characteristics including distribution, filling defect, and intensity were observed on T1-, T2-, and fat-suppressed T2-weighted imaging, DWI, and contrast-enhanced MRI. Apparent diffusion coefficient (ADC) values were calculated.

 

RESULTS: Six patients were pathologically diagnosed as PAS and the other five as chronic PTE. There were no significant differences in age, gender, presenting symptoms, D-dimer, and N-terminal pro-brain natriuretic peptide between the two groups (P > 0.05). Among MRI findings that were tested for their ability to diagnose PAS, area under the curve (AUC) was significantly higher than 0.5 for main pulmonary artery involvement (AUC, 0.83±0.13; P = 0.011), hyperintensity on fat-suppressed T2-weighted imaging (AUC, 0.82±0.14; P = 0.025), hyperintensity on DWI (AUC, 0.88±0.12; P = 0.002), contrast enhancement (AUC, 0.92±0.10; P < 0.001) and pleural effusion (AUC, 0.82±0.14; P = 0.025). Moreover, grape-like appearance in distal pulmonary artery and cardiac invasion had 100% specificity for diagnosis of PAS. However, ADC value of PAS was not significantly different than that of chronic PTE (U, 12.00; P = 0.584).

 

CONCLUSION: Hyperintense filling defect in main pulmonary artery on fat-suppressed T2-weighted imaging and DWI and contrast enhancement may help to discriminate PAS from PTE.

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