E-ISSN 1305-3612
Chest Imaging - Original Article
Dynamic contrast-enhanced MR imaging for advanced esophageal cancer response assessment after concurrent chemoradiotherapy
1 Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China  
2 Departments of Radiotherapy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China  
Diagn Interv Radiol ; : -

Abstract

 

Purpose: We aimed to evaluate the treatment response of patients with esophageal cancer after concurrent chemoradiation therapy (CRT) by Dynamic contrast-enhanced MR imaging (DCE-MRI).

 

Methods: This retrospective study was enrolled 59 patients with histologically confirmed esophageal squamous cell carcinoma. The patients underwent DCE-MRI before and 4 weeks after CRT. The complete response (CR) patients were defined as the CR group; the partial response (PR), stable disease (SD), and progressive disease (PD) patients were defined as the non-CR group. DCE-MRI parameters (Ktrans, ve, and kep) were measured and compared between pre- and post-CRT in the CR and non-CR groups, respectively. Pre-CRT and post-CRT parameters were used to calculate change value (ΔX) and ratio (rΔX). Comparisons of the DCE-MRI parameters were performed between the CR and non-CR groups. Receiver operating characteristic (ROC) curves were used to verify diagnostic performance.

 

Results: Patients with higher T-stage esophageal cancer might be presented with poorer response. After CRT, the Ktrans and Kep values significantly decreased in the CR group, whereas only kep value decreased in the non-CR group. The post-Ktrans and post-Kep values were observed to be significantly lower in the CR group than those in the non-CRT group. The change values and ratios of Ktrans and Kep were all higher in the CR group than those in the non-CRT group. Based on ROC analysis, rΔKtrans had the highest area under the curve of 0.840 in assessing response.

 

Conclusion: DCE-MRI parameters are valuable in predicting and assessing concurrent chemoradiation therapy response for advanced esophageal cancer.

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